Structure and Function of Enterocyte in Intrauterine Growth Retarded Pig Neonates
Joint Authors
Zabielski, Romuald
Gajewski, Zdzisław
Ferenc, Karolina
Pilżys, Tomasz
Skrzypek, Tomasz
Garbicz, Damian
Marcinkowski, Michał
Dylewska, Małgorzata
Gładysz, Paweł
Skorobogatov, Oleksandr
Grzesiuk, Elżbieta
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The intestine of intrauterine growth retarded (IUGR) neonates showed different morphology compared to neonates born with normal body weight (NBW).
The aim of the present study was to investigate the ultrastructure and proteomic profile of the gut epithelium in IUGR pig neonates with special attention to the digestive and absorptive function.
Intestine tissue samples were investigated in 7-day-old IUGR and NBW littermate piglets using histometry, immunofluorescence, scanning electron microscopy (SEM), and mass spectrometry analysis.
IUGR piglets have shown reduced mucosa and muscularis thickness and an enhanced number of foetal type enterocytes (FTE).
SEM studies have shown the lack of the characteristic large-size vacuole in IUGR’s enterocytes.
Delayed removal of FTE in IUGR neonates was probably due to the inhibited apoptosis in the apical part of villi and increased apoptosis and reduced mitosis in the crypt region.
In the expression of proteins in the intestinal mucosa such as hexokinase I, histones, and prelamin A/C, carbamoyl phosphate was reduced in IUGR neonates.
Finally, IUGR intestines showed higher expression of HSPA9 and HSPA5 as apoptosis markers.
The data indicate modifications of gut mucosa in IUGRs that may result in slower gut mucosa maturation and reduced utilisation of nutrient as compared to NBW pig neonates.
American Psychological Association (APA)
Ferenc, Karolina& Pilżys, Tomasz& Skrzypek, Tomasz& Garbicz, Damian& Marcinkowski, Michał& Dylewska, Małgorzata…[et al.]. 2017. Structure and Function of Enterocyte in Intrauterine Growth Retarded Pig Neonates. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152368
Modern Language Association (MLA)
Ferenc, Karolina…[et al.]. Structure and Function of Enterocyte in Intrauterine Growth Retarded Pig Neonates. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152368
American Medical Association (AMA)
Ferenc, Karolina& Pilżys, Tomasz& Skrzypek, Tomasz& Garbicz, Damian& Marcinkowski, Michał& Dylewska, Małgorzata…[et al.]. Structure and Function of Enterocyte in Intrauterine Growth Retarded Pig Neonates. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152368