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The Effect of Sex Differences on Endothelial Function and Circulating Endothelial Progenitor Cells in Hypertriglyceridemia
Joint Authors
Zeng, Haitao
Ren, Zi
Guo, Jiayi
Xiao, Xingxing
Huang, Jiana
Li, Manchao
Cai, Ruibin
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Men have a higher risk and earlier onset of cardiovascular diseases compared with premenopausal women.
Hypertriglyceridemia is an independent risk factor for the occurrence of ischemic heart disease.
Endothelial dysfunction is related to the development of ischemic heart disease.
Whether sex differences will affect the circulating endothelial progenitor cells (EPCs) and endothelial function in hypertriglyceridemia patients or not is not clear.
Methods.
Forty premenopausal women and forty age- and body mass index (BMI)-matched men without cardiovascular and metabolic disease were recruited and then divided into four groups: normotriglyceridemic women (women with serum triglycerides level <150 mg/dl), hypertriglyceridemic women (women with serum triglycerides level ≥150 mg/dl), normotriglyceridemic men (men with serum triglycerides level <150 mg/dl), and hypertriglyceridemic men (men with serum triglycerides level ≥150 mg/dl).
Peripheral blood was obtained and evaluated.
Flow-mediated dilatation (FMD), the number and activity of circulating EPCs, and the levels of nitric oxide (NO), vascular endothelial growth factor (VEGF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma and culture medium were measured.
Results.
The number and activity of circulating EPCs, as well as the level of NO in plasma or culture medium, were remarkably increased in premenopausal females compared with those in males both in the hypertriglyceridemic group and the normotriglyceridemic group.
The EPC counts and activity, as well as the production of NO, were restored in hypertriglyceridemic premenopausal women compared with those in normal women.
However, in hypertriglyceridemic men, the EPC counts and activity, as well as levels of NO, were significantly reduced.
The values of VEGF and GM-CSF were without statistical change.
Conclusions.
The present study firstly demonstrated that there were sex differences in the number and activity of circulating EPCs in hyperglyceridemia patients.
Hypertriglyceridemic premenopausal women displayed restored endothelial functions, with elevated NO production, probably mediated by estradiol.
We provided a new insight to explore the clinical biomarkers and therapeutic strategies for hypertriglyceridemia-related vascular damage.
American Psychological Association (APA)
Ren, Zi& Guo, Jiayi& Xiao, Xingxing& Huang, Jiana& Li, Manchao& Cai, Ruibin…[et al.]. 2020. The Effect of Sex Differences on Endothelial Function and Circulating Endothelial Progenitor Cells in Hypertriglyceridemia. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152370
Modern Language Association (MLA)
Ren, Zi…[et al.]. The Effect of Sex Differences on Endothelial Function and Circulating Endothelial Progenitor Cells in Hypertriglyceridemia. Cardiology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1152370
American Medical Association (AMA)
Ren, Zi& Guo, Jiayi& Xiao, Xingxing& Huang, Jiana& Li, Manchao& Cai, Ruibin…[et al.]. The Effect of Sex Differences on Endothelial Function and Circulating Endothelial Progenitor Cells in Hypertriglyceridemia. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152370