Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients
Joint Authors
Mozos, Ioana
Caraba, Alexandru
Crişan, Viorica
Romoşan, Ioan
Murariu, Marius
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis.
The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA.
Material and Methods.
The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls.
In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction.
Statistical analysis were performed using the Student’s t-test and the Pearson’s test.
p values of less than 0.05 were considered statistically significant.
Results.
The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001).
Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated.
Conclusion.
In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.
American Psychological Association (APA)
Caraba, Alexandru& Crişan, Viorica& Romoşan, Ioan& Mozos, Ioana& Murariu, Marius. 2017. Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152373
Modern Language Association (MLA)
Caraba, Alexandru…[et al.]. Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152373
American Medical Association (AMA)
Caraba, Alexandru& Crişan, Viorica& Romoşan, Ioan& Mozos, Ioana& Murariu, Marius. Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152373