Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis
Joint Authors
Koch, Alexander
Yagmur, Eray
Bruensing, Jan
Herbers, Ulf
Baeck, Christer
Trautwein, Christian
Tacke, Frank
Buendgens, Lukas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β superfamily related to inflammation and macrophage activation.
Serum concentrations of GDF-15 can predict poor survival in chronic diseases, but its role in sepsis is obscure.
Therefore, we investigated GDF-15 as a prognostic biomarker in critically ill patients.
We measured GDF-15 levels in 219 critically ill patients (146 with sepsis, 73 without sepsis) upon admission to the intensive care unit (ICU), in comparison to 66 healthy controls.
GDF-15 levels were significantly increased in ICU patients compared to controls.
GDF-15 was further increased in sepsis and showed a strong association with organ dysfunction (kidney, liver and lactate) and disease severity (APACHE II and SOFA score).
High GDF-15 concentrations at admission independently predicted ICU (HR 3.42; 95% CI 1.33–8.78) and overall mortality (HR 2.02, 95% CI 1.02–3.88) in all ICU critically ill patients as well as in a large subgroup of sepsis patients (ICU mortality: HR 3.16; 95% CI 1.10–9.07; overall mortality: HR 2.62; 95% CI 1.14–6.02).
Collectively, serum GDF-15 levels are significantly increased in critically ill patients, associated with sepsis, organ failure, and disease severity.
High GDF-15 levels at ICU admission predict short- and long-term mortality risk.
American Psychological Association (APA)
Buendgens, Lukas& Yagmur, Eray& Bruensing, Jan& Herbers, Ulf& Baeck, Christer& Trautwein, Christian…[et al.]. 2017. Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152375
Modern Language Association (MLA)
Buendgens, Lukas…[et al.]. Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152375
American Medical Association (AMA)
Buendgens, Lukas& Yagmur, Eray& Bruensing, Jan& Herbers, Ulf& Baeck, Christer& Trautwein, Christian…[et al.]. Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152375