Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs
Joint Authors
Han, Fei
Luo, Fanyan
Chen, Yubin
Liu, Fen
Lv, Lizhi
Tang, Can-e
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Endothelial cell injury is a critical pathological change during the development of atherosclerosis.
Here, we explored the effect of omentin-1 on free fatty acid- (FFA-) induced endothelial cell injury.
Methods.
An FFA-induced endothelial cell injury model was established to investigate the role of omentin-1 in this process.
Cell proliferation was analyzed with the Cell Counting Kit assay and flow cytometry.
Scratch and transwell assays were used to evaluate cell migration.
Factors secreted by endothelial cells after injury were detected by western blotting, reverse-transcription quantitative polymerase chain reaction, and cellular fluorescence assay.
Results.
Omentin-1 rescued the FFA-induced impaired proliferation and migration capabilities of human umbilical vein endothelial cells (HUVECs).
It decreased the number of THP-1 cells attached to HUVECs in response to injury and inhibited the FFA-induced proinflammatory state of HUVECs.
Conclusion.
Omentin-1 could partly ameliorate FFA-induced endothelial cell injury.
American Psychological Association (APA)
Chen, Yubin& Liu, Fen& Han, Fei& Lv, Lizhi& Tang, Can-e& Luo, Fanyan. 2020. Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152387
Modern Language Association (MLA)
Chen, Yubin…[et al.]. Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs. Cardiology Research and Practice No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1152387
American Medical Association (AMA)
Chen, Yubin& Liu, Fen& Han, Fei& Lv, Lizhi& Tang, Can-e& Luo, Fanyan. Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152387