Impact of Vaccination on Distribution of T Cell Subsets in Antiretroviral-Treated HIV-Infected Children
Joint Authors
Ammaranond, Palanee
Thitilertdecha, Premrutai
Khowawisetsut, Ladawan
Poungpairoj, Poonsin
Tantithavorn, Varangkana
Onlamoon, Nattawat
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antiretroviral therapy (ART) is generally prescribed to patients with human immunodeficiency virus (HIV) infection with vaccination introduced to prevent disease complications.
However, little is known about the influence of immunization on T cell subsets’ distribution during the course of infection.
This study aims to identify the impact of viral replication and immunization on naïve, effector, effector memory, and central memory T cell subpopulations in ART-treated HIV-infected children.
Fifty patients were recruited and injected intramuscularly with influenza A (H1N1) 2009 vaccine on the day of enrollment (day 0) and day 28.
Blood samples were collected for pre- and postvaccination on days 0 and 56 for analyzing T cell phenotypes by flow cytometry.
Phenotypes of all T cell subsets remained the same after vaccination, except for a reduction in effector CD8+ T cells.
Moreover, T cell subsets from patients with controllable viral load showed similar patterns to those with virological failure.
Absolute CD4 count was also found to have a positive relationship with naïve CD4+ and CD8+ T cells.
In conclusion, vaccination and viral replication have a little effect on the distribution of T cell subpopulations.
The CD4 count can be used for prediction of naïve T cell level in HIV-infected patients responding to ART.
American Psychological Association (APA)
Thitilertdecha, Premrutai& Khowawisetsut, Ladawan& Ammaranond, Palanee& Poungpairoj, Poonsin& Tantithavorn, Varangkana& Onlamoon, Nattawat. 2017. Impact of Vaccination on Distribution of T Cell Subsets in Antiretroviral-Treated HIV-Infected Children. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152394
Modern Language Association (MLA)
Thitilertdecha, Premrutai…[et al.]. Impact of Vaccination on Distribution of T Cell Subsets in Antiretroviral-Treated HIV-Infected Children. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152394
American Medical Association (AMA)
Thitilertdecha, Premrutai& Khowawisetsut, Ladawan& Ammaranond, Palanee& Poungpairoj, Poonsin& Tantithavorn, Varangkana& Onlamoon, Nattawat. Impact of Vaccination on Distribution of T Cell Subsets in Antiretroviral-Treated HIV-Infected Children. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152394