Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients
Joint Authors
Hussein, Ihsan A.
Jaber, Saddam H.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study is the first investigation in Iraq dealing with genotyping of IL-4 −590 (C>T) gene, especially in Iraqi patients with asthma.
We studied forty-eight blood samples collected from patients with asthma and compared with age-matched 25 healthy individuals as controls.
The polymorphism results of IL-4 −590 (C>T) gene by using amplification refractory mutation system (ARMS-PCR) showed the presence of C and T alleles and three genotypes (CC, CT, and TT).
Interestingly the frequency of C allele and CC genotype was higher in patients with asthma in comparison with the same allele and genotype in control (P 1 × 10−6).
This increase was associated with an increased risk factor of asthma (odds ratio [OR] 9.21; 95% confidence interval [CI] 3.58–23.71).
Genotypes analysis by using Hardy-Weinberg distribution showed no significant differences between patients with asthma and healthy subjects.
In conclusion, the increasing risk of asthma was associated with C allele and the CC genotype and these are revealed as etiological fraction with risk by having this disease, while the T allele percentage ratio in controls was higher when it is compared with asthma patients suggesting that these alleles have a protective effect (preventive fraction).
American Psychological Association (APA)
Hussein, Ihsan A.& Jaber, Saddam H.. 2017. Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152403
Modern Language Association (MLA)
Hussein, Ihsan A.& Jaber, Saddam H.. Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152403
American Medical Association (AMA)
Hussein, Ihsan A.& Jaber, Saddam H.. Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152403