Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Abstract EN

Purpose.

To determine if the MMP-9 genotype has an influence on development of pituitary adenoma (PA).

Methodology.

The study enrolled n=86 patients with PA and n=526 healthy controls (reference group).

The genotyping of MMP-9 was carried out using the real-time polymerase chain reaction method.

Results.

Our data demonstrated that the MMP-9 (–1562) C/C genotype was more frequent in PA group than in healthy controls (81.4% versus 64.6%, p=0.002); C/C genotype was more frequently present in PA females compared to healthy control females, 81.5% versus 64.6%, p=0.018, as well.

MMP-9 (–1562) C/C genotype was frequently observed for all subgroups: noninvasive and invasive, nonrecurrence, and inactive PA compared to healthy controls: 81.8% versus 64.6%, p=0.021; 81.0% versus 64.6%, p=0.041; 81.8% versus 64.6%, p=0.005; 100.0% versus 64.6%, p<0.001, respectively.

MMP-9 (–1562) C/C genotype was more frequent in inactive PA compared to active PA: 100.0% versus 71.4%; p<0.001.

Conclusion.

MMP-9 (–1562) C/C genotype plays a role in nonrecurrence, inactive, and invasive as well as in nonivasive PA development.