Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis
Joint Authors
Wang, Canhong
Peng, Deqian
Liu, Yangyang
Yu, Zhangxin
Guo, Peng
Wei, Jianhe
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Agarwood is a traditional medicine used for treating some diseases, including painful and ischemic diseases.
This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-) induced myocardial ischemia (MI) in rats and explore the underlying molecular mechanisms.
Compared to the MI group, WTAAE pretreatment significantly improved ST wave abnormal-elevation, mitigated myocardial histological damage; decreased creatinine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced hydrogen peroxide (H2O2) and lipid peroxide (LPO) production; and increased total antioxidant capacity (T-AOC) and catalase (CAT) activities.
Moreover, agarwood alcohol extracts (AAEs) markedly enhanced the mRNA levels of Nrf2-ARE pathway, and Bcl-2 reduced the apoptotic Bax family mRNA expressions.
In addition, the effect of WTAAE was greater than that of wild agarwood alcohol extract (WAAE) and burning-chisel-drilling agarwood alcohol extract (FBAAE).
All of these data indicate that WTAAE exerted the protective effects of MI, and its mechanism was associated with upregulating Nrf2-ARE and suppressing Bcl-2 pathways.
American Psychological Association (APA)
Wang, Canhong& Peng, Deqian& Liu, Yangyang& Yu, Zhangxin& Guo, Peng& Wei, Jianhe. 2020. Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152414
Modern Language Association (MLA)
Wang, Canhong…[et al.]. Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis. Cardiology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1152414
American Medical Association (AMA)
Wang, Canhong& Peng, Deqian& Liu, Yangyang& Yu, Zhangxin& Guo, Peng& Wei, Jianhe. Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152414