The Ratio of C-Reactive ProteinAlbumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma
Joint Authors
An, Xin
Sun, Peng
Chen, Cui
Xia, Yi
Bi, Xiwen
Liu, Panpan
Zhang, Fei
Yang, Hang
Jiang, Wenqi
Wang, Fenghua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The C-reactive protein/albumin (CRP/Alb) ratio has been recently identified as a prognostic factor in various cancers, whereas its role remains unclear in metastatic nasopharyngeal carcinoma (NPC).
The current study retrospectively analyzed 148 patients with metastatic NPC who underwent cisplatin-based chemotherapy and further evaluated the prognostic value of the CRP/Alb ratio and its association with clinical characteristics in these patients.
The optimal cut-off value was 0.189 for the CRP/Alb ratio.
The high CRP/Alb ratio was significantly associated with elevated NLR, platelet-to-lymphocyte ratio (PLR), and EBV-DNA levels and decreased haemoglobin level (all p<0.05).
The results of multivariate analysis showed that the CRP/Alb ratio was an independent prognostic factor of overall survival.
Patients with a high CRP/Alb ratio (≥0.189) had a 1.867 times (p=0.024, 95% CI=1.085–3.210) greater risk of mortality compared with those with a low CRP/Alb ratio (<0.189).
In addition, combining the CRP/Alb ratio with GPS could accurately discriminate the prognosis of our patients.
Our results suggested that the CRP/Alb ratio is a feasible and inexpensive tool for predicting survival outcomes and is a valuable coadjutant for the GPS to further identify differences in survivals of patients with metastatic NPC.
American Psychological Association (APA)
Sun, Peng& Chen, Cui& Xia, Yi& Bi, Xiwen& Liu, Panpan& Zhang, Fei…[et al.]. 2017. The Ratio of C-Reactive ProteinAlbumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152440
Modern Language Association (MLA)
Sun, Peng…[et al.]. The Ratio of C-Reactive ProteinAlbumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152440
American Medical Association (AMA)
Sun, Peng& Chen, Cui& Xia, Yi& Bi, Xiwen& Liu, Panpan& Zhang, Fei…[et al.]. The Ratio of C-Reactive ProteinAlbumin is a Novel Inflammatory Predictor of Overall Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152440