Clinical Relevance of NGALMMP-9 Pathway in Patients with Endometrial Cancer
Joint Authors
Machalinski, Boguslaw
Pius-Sadowska, Ewa
Cymbaluk-Płoska, Aneta
Chudecka-Głaz, Anita
Menkiszak, Janusz
Sompolska-Rzechuła, Agnieszka
Chudecka, Karolina
Bulsa, Michał
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objectives of the study were to assess the relationship between the serum levels of MMP-9 and NGAL and the clinical staging and histopathological grade of the tumor.
Lipocalin-2/NGAL and MMP-9 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA).
The AUC values for NGAL and MMP-9 were 0.9 and 0.78, respectively.
The diagnostic potential of NGAL and MMP-9 in differentiating high-stage (FIGO III and IV) and low-stage (FIGO I and II) cancer and predicting the cell differentiation grade (G1 versus G3) on the basis of the analyses of AUC values was determined to be 0.91 and 0.79 for NGAL and 0.82 and 0.84 for MMP-9, respectively.
Multifactorial logistic regression analysis in the final method revealed that NGAL and MMP-9 variables were independent of the endometrial cancer risk.
OR values for NGAL and MMP-9 were 1.23 (95% CI 1.421–3.27; p=0.034) and 1.09 (95% CI: 1.38–4.12; p=0.026), respectively.
The NGAL/MMP-9 complex may be useful in the assessment of tumor stage before surgical treatment.
American Psychological Association (APA)
Cymbaluk-Płoska, Aneta& Chudecka-Głaz, Anita& Pius-Sadowska, Ewa& Sompolska-Rzechuła, Agnieszka& Chudecka, Karolina& Bulsa, Michał…[et al.]. 2017. Clinical Relevance of NGALMMP-9 Pathway in Patients with Endometrial Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152443
Modern Language Association (MLA)
Cymbaluk-Płoska, Aneta…[et al.]. Clinical Relevance of NGALMMP-9 Pathway in Patients with Endometrial Cancer. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152443
American Medical Association (AMA)
Cymbaluk-Płoska, Aneta& Chudecka-Głaz, Anita& Pius-Sadowska, Ewa& Sompolska-Rzechuła, Agnieszka& Chudecka, Karolina& Bulsa, Michał…[et al.]. Clinical Relevance of NGALMMP-9 Pathway in Patients with Endometrial Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152443