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Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases
Joint Authors
Koo, Ja Seung
Cha, Yoon Jin
Jung, Woo Hee
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
We aimed to investigate the expression of pentose phosphate pathway- (PPP-) related proteins in metastatic breast cancer and its relationship with clinicopathologic factors.
Methods.
Tissue samples from 126 metastatic breast cancers were included in a tissue microarray.
Expression of PPP-related proteins [glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL), 6-phosphogluconate dehydrogenase (6PGDH), and nuclear factor erythroid 2-related factor (NRF2)] was determined by immunohistochemistry.
Results.
G6PDH (p=0.011) and cytoplasmic NRF2 (p=0.001) showed the highest expression in brain metastases.
Human epidermal growth factor receptor (HER-2) positivity was associated with G6PDH (p<0.001) and cytoplasmic NRF2 (p=0.015) positivity.
A high Ki-67 labeling index (LI) was correlated with nuclear NRF2 positivity (p=0.037), and HER-2-positive luminal B type was associated with G6PDH positivity (p=0.001).
On multivariate Cox analysis, independent risk factors of short overall survival were 6PGL positivity in bone metastasis (HR 4.180, 95% CI 1.160–15.06, p=0.029) and low Ki-67 LI in lung metastasis (HR 11.853, 95% CI 1.841–76.30, p=0.009).
Conclusion.
Differential expression of PPP-related proteins correlated with different prognoses and metastatic sites, with the highest expression in brain metastases, and could be a potential therapeutic target.
American Psychological Association (APA)
Cha, Yoon Jin& Jung, Woo Hee& Koo, Ja Seung. 2017. Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152466
Modern Language Association (MLA)
Cha, Yoon Jin…[et al.]. Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152466
American Medical Association (AMA)
Cha, Yoon Jin& Jung, Woo Hee& Koo, Ja Seung. Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152466