Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Joint Authors
Jiang, Yu-yong
He, Lingling
Liu, Xiaoli
Zhao, Yalin
Zhang, Shuan
Wang, Xianbo
Yang, Zhiyun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
To determine whether nucleot(s)ide analogs therapy has survival benefit for patients with HBV-related HCC after unresectable treatment.
Method.
A systematic search was conducted through seven electronic databases including PubMed, OVID, EMBASE, Cochrane Databases, Elsevier, Wiley Online Library, and BMJ Best Practice.
All studies comparing NA combined with unresectable treatment versus unresectable treatment alone were considered for inclusion.
The primary outcome was the overall survival (OS) after unresectable treatment for patients with HBV-related HCC.
The secondary outcome was the progression-free survival (PFS).
Results were expressed as hazard ratio (HR) for survival with 95% confidence intervals.
Results.
We included six studies with 994 patients: 409 patients in nucleot(s)ide analogs therapy group and 585 patients without antiviral therapy in control group.
There were significant improvements for the overall survival (HR = 0.57; 95% CI = 0.47–0.70; p < 0.001) and progression-free survival (HR = 0.84; 95% CI = 0.71–0.99; p = 0.034) in the NA-treated group compared with the control group.
Funnel plot showed that there was no significant publication bias in these studies.
When it comes to antiviral drugs and operation method, it also showed benefit in NA-treated group.
At the same time, overall mortality as well as mortality secondary to liver failure in NA-treated group was obviously lesser.
Sensitivity analyses confirmed the robustness of the results.
Conclusions.
Nucleot(s)ide analogs therapy after unresectable treatment has potential beneficial effects in terms of overall survival and progression-free survival.
NA therapy should be considered in clinical practice.
American Psychological Association (APA)
He, Lingling& Liu, Xiaoli& Zhao, Yalin& Zhang, Shuan& Jiang, Yu-yong& Wang, Xianbo…[et al.]. 2017. Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152471
Modern Language Association (MLA)
He, Lingling…[et al.]. Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152471
American Medical Association (AMA)
He, Lingling& Liu, Xiaoli& Zhao, Yalin& Zhang, Shuan& Jiang, Yu-yong& Wang, Xianbo…[et al.]. Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152471