Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients
Joint Authors
Zhou, Yujie
Nie, Shaoping
Que, Bin
Cheng, Guojie
Ma, Ning
Huang, Ying
Zhou, Qi
Dong, Jianzeng
Lin, Ying-zhong
Ji, Qing-wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Evidence from experimental studies showed that Th1, Th2, and Th17 play a pivotal role in hypertension and target organ damage.
However, whether changes in the circulating Th1, Th2, and Th17 levels are associated with nondipper hypertension and carotid atherosclerotic plaque in hypertension has yet to be investigated.
Methods.
Th1, Th2, and Th17 levels were detected using a flow cytometric analysis, and their related cytokines were measured by enzyme-linked immunosorbent assay in 45 hypertensive patients and 15 normotensive subjects.
Results.
The frequencies of Th1 and Th17 in hypertensive patients, especially in nondipper patients and patients with carotid atherosclerotic plaque, were markedly higher than those in the control group; this was accompanied by higher IFN-γ and IL-17 levels.
In contrast, the Th2 frequencies and IL-4 levels in hypertensive patients, especially in nondipper patients and patients with carotid atherosclerotic plaque, were significantly lower than those in the control group.
Conclusions.
The changes in Th1, Th2, and Th17 activity are associated with the onset of the nondipper type and carotid atherosclerotic plaque in hypertensive patients.
American Psychological Association (APA)
Ji, Qing-wei& Cheng, Guojie& Ma, Ning& Huang, Ying& Lin, Ying-zhong& Zhou, Qi…[et al.]. 2017. Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1152479
Modern Language Association (MLA)
Ji, Qing-wei…[et al.]. Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients. Disease Markers No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1152479
American Medical Association (AMA)
Ji, Qing-wei& Cheng, Guojie& Ma, Ning& Huang, Ying& Lin, Ying-zhong& Zhou, Qi…[et al.]. Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1152479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152479