The Nrf-2HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases
Joint Authors
Zhu, Ping
Zhao, Mingyi
Zhang, Xueyan
Yu, Yihan
Lei, Hanyu
Cai, Yufeng
Shen, Jie
He, Qingnan
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health.
Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular disease.
Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body.
It is activated, transferred to the nucleus, and bound to DNA by antioxidant response elements (AREs).
As a regulator of the antioxidant system, it upregulates the expression of HO-1 to reduce oxidative stress.
Nrf2/HO-1 also has the ability to modulate calcium levels to prevent ferroptosis, pyroptosis, autophagy, programmed cell necrosis, alkaliptosis, and clockophagy.
In view of the importance of Nrf2/HO-1 in the regulation of homeostasis, this review summarizes current research on the relationship between cardiovascular disease and Nrf2/HO-1.
Normal cardiovascular diseases, such as viral myocarditis and myocardial ischemia-reperfusion injury, have been treated with Nrf2/HO-1.
Rheumatic heart disease, cardiac tumors, arteriosclerosis, arrhythmia, hypertensive heart disease, and myocardial infarction have also been treated during experiments.
Research has demonstrated the clinical application of Nrf2/HO-1 in pediatric cardiovascular disease; further clinical trials will help elucidate the potential of the Nrf2/HO-1 signaling axis.
American Psychological Association (APA)
Zhang, Xueyan& Yu, Yihan& Lei, Hanyu& Cai, Yufeng& Shen, Jie& Zhu, Ping…[et al.]. 2020. The Nrf-2HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152490
Modern Language Association (MLA)
Zhang, Xueyan…[et al.]. The Nrf-2HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases. Cardiology Research and Practice No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1152490
American Medical Association (AMA)
Zhang, Xueyan& Yu, Yihan& Lei, Hanyu& Cai, Yufeng& Shen, Jie& Zhu, Ping…[et al.]. The Nrf-2HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152490