Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
Joint Authors
Li, Xiang
Yao, Shun
Ren, Zi
Zeng, Haitao
Wu, Shaohong
Liao, Jinli
He, Hao
Liu, Ge-Xiu
Li, Xiao-Peng
Su, Huan-Xing
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background/Aims.
Sexual differences exist in endothelial progenitor cells (EPCs), and various cardiovascular risk factors are associated with the preservation of endothelial function in premenopausal women.
However, it is unclear whether differences in endothelial function and circulating EPCs exist between overweight premenopausal women and age-matched men.
Methods.
We compared EPC counting and functions in normal-weight and overweight premenopausal women and men, evaluated endothelial function in each group, and detected the expression of the guanosine triphosphate cyclohydrolase I (GTPCH I) pathway.
Results.
The number of EPCs was lower in the male group than in the female group, regardless of normal-weight or overweight status, and there was no significant difference between the different weight groups among females or males.
Endothelial function and EPC migration and proliferation were preserved in overweight premenopausal women compared with overweight men as were nitric oxide (NO) levels in plasma and secreted by EPCs.
Endothelial function, the circulating EPC population, and NO levels were not different between normal-weight and overweight premenopausal women.
Flow-mediated dilatation was significantly correlated with EPC function, plasma NO levels, and EPC-secreted NO.
Conclusions.
This investigation provides the first evidence for sex-based differences in EPC activity and endothelial function in overweight middle-aged individuals; these differences are associated with alterations in NO production and may partly occur through downregulation of the GTPCH I pathway.
The present results provide new insights into the mechanism underlying the preserved endothelial function in overweight premenopausal women and may uncover a potential therapeutic target for endothelial repair in overweight population.
American Psychological Association (APA)
Wu, Shaohong& He, Hao& Liu, Ge-Xiu& Li, Xiao-Peng& Yao, Shun& Su, Huan-Xing…[et al.]. 2020. Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1152504
Modern Language Association (MLA)
Wu, Shaohong…[et al.]. Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women. Cardiology Research and Practice No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1152504
American Medical Association (AMA)
Wu, Shaohong& He, Hao& Liu, Ge-Xiu& Li, Xiao-Peng& Yao, Shun& Su, Huan-Xing…[et al.]. Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1152504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152504