The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention
Joint Authors
Strzelczyk, Joanna Katarzyna
Bujak, Kamil
Osadnik, Tadeusz
Gąsior, Mariusz
Lekston, Andrzej
Poloński, Lech
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aim.
The specific association between genetic variation and in-stent restenosis is still only partly understood.
The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-β1; rs1800470) and target lesion revascularization (TLR) risk.
Methods.
A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included.
The primary study endpoint was TLR at a 4-year follow-up.
Results.
The TLR rate was higher in patients with the VEGFA A/A genotype (15.4%) than in patients with the VEGFA A/C (7.9%) and C/C (8.9%) genotypes (p=0.009).
The VEGFA A/A genotype, after adjustment for clinical and procedural covariates, remained significantly and independently associated with the TLR (hazard ratio—2.09 [95% confidence interval 1.32–3.33, p=0.0017]).
However, we found no association between TLR and the TGFB1 genotype.
Conclusion.
The VEGFA A/A genotype is significantly and independently associated with TLR risk in Polish SCAD patients who received elective PCI with bare-metal stent implantation.
American Psychological Association (APA)
Osadnik, Tadeusz& Lekston, Andrzej& Bujak, Kamil& Strzelczyk, Joanna Katarzyna& Poloński, Lech& Gąsior, Mariusz. 2017. The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152515
Modern Language Association (MLA)
Osadnik, Tadeusz…[et al.]. The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152515
American Medical Association (AMA)
Osadnik, Tadeusz& Lekston, Andrzej& Bujak, Kamil& Strzelczyk, Joanna Katarzyna& Poloński, Lech& Gąsior, Mariusz. The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152515