The Role of IL-33 in Experimental Heart Transplantation
Joint Authors
Duan, Lihua
He, Yan
Xie, Zhongming
Wei, Yingying
Chen, Jie
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Interleukin-33 (IL-33) is a member of the IL-1 family of proteins that are produced by a variety of cell types in multiple tissues.
Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an “alarmin” upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment.
To date, numerous studies have investigated the roles of IL-33 in human and murine models of diseases of the nervous system, digestive system, pulmonary system, as well as other organs and systems, including solid organ transplantation.
With graft rejection and ischemia-reperfusion injury being the most common causes of grafted organ failure or dysfunction, researchers have begun to investigate the role of IL-33 in the immune-related mechanisms of graft tolerance and rejection using heart transplantation models.
In the present review, we summarize the identified roles of IL-33 as well as the corresponding mechanisms by which IL-33 acts within the progression of graft rejection after heart transplantation in animal models.
American Psychological Association (APA)
Chen, Jie& He, Yan& Xie, Zhongming& Wei, Yingying& Duan, Lihua. 2020. The Role of IL-33 in Experimental Heart Transplantation. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152516
Modern Language Association (MLA)
Chen, Jie…[et al.]. The Role of IL-33 in Experimental Heart Transplantation. Cardiology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1152516
American Medical Association (AMA)
Chen, Jie& He, Yan& Xie, Zhongming& Wei, Yingying& Duan, Lihua. The Role of IL-33 in Experimental Heart Transplantation. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152516