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Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy
Joint Authors
Nakazone, Marcelo A.
Otaviano, Ana Paula
Rodrigues, Ana Maria Silveira
Cardinalli-Neto, Augusto
Bestetti, Reinaldo Bulgarelli
Machado, Maurício N.
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Few studies regarding chronic kidney disease (CKD) and anemia have been conducted in patients with Chagas cardiomyopathy (CC).
We evaluated the risk prediction performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and anemia in CC patients.
Methods.
From 2000 to 2010, a total of 232 patients were studied in a single-center retrospective study.
CKD was defined as creatinine clearance <60 mL/min/1.73 m2 according to CKD-EPI equation.
Anemia was defined as hemoglobin <12 g/dL (women) and <13 g/dL (men).
Cox proportional hazards models were used to establish predictors for death.
Results.
At baseline, 98 individuals (42.2%) had criteria for CKD and 41 (17.7%) for anemia.
During follow-up, 136 patients (58.6%) died.
Independently, CKD and anemia were not associated with all-cause mortality.
However, when they coexisted, an additional risk was attributed for these patients.
Cox proportional hazard models analysis identified systolic blood pressure (hazard ratio, 0.99; 95% confidence interval (CI), 0.98 to 1.00; P=0.015), implantable cardioverter-defibrillator (hazard ratio, 0.48; 95% CI, 0.27 to 0.85; P=0.012), left anterior fascicular block (hazard ratio, 1.52; 95% CI, 1.08 to 2.13; P=0.017), left ventricular end-diastolic diameter (hazard ratio, 1.04; 95% CI, 1.02 to 1.06; P<0.001), and serum sodium (hazard ratio, 0.95; 95% CI, 0.92 to 0.99; P=0.020) as independent predictors for death.
Conclusions.
CKD and anemia are not independent predictors for long-term mortality in CC patients.
However, the prognosis is poorer in individuals with both comorbidities.
American Psychological Association (APA)
Nakazone, Marcelo A.& Machado, Maurício N.& Otaviano, Ana Paula& Rodrigues, Ana Maria Silveira& Cardinalli-Neto, Augusto& Bestetti, Reinaldo Bulgarelli. 2020. Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152523
Modern Language Association (MLA)
Nakazone, Marcelo A.…[et al.]. Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy. Cardiology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1152523
American Medical Association (AMA)
Nakazone, Marcelo A.& Machado, Maurício N.& Otaviano, Ana Paula& Rodrigues, Ana Maria Silveira& Cardinalli-Neto, Augusto& Bestetti, Reinaldo Bulgarelli. Prognostic Significance of Chronic Kidney Disease (CKD-EPI Equation) and Anemia in Patients with Chronic Heart Failure Secondary to Chagas Cardiomyopathy. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152523