Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients
Joint Authors
Eliseeva, Tatyana I.
Kubysheva, Nailya I.
Postnikova, Larisa
Soodaeva, Svetlana
Novikov, Viкtor
Batyrshin, Ildar
Li, Timur
Klimanov, Igor
Chuchalin, Alexander
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease.
We investigated 91 patients with COPD and 21 healthy nonsmokers.
The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied.
An unidirectional change in the content of sCD25, sCD38, and sCD8 molecules with increasing severity of COPD was detected.
The correlations between the parameters of lung function and sCD8, sCD25, and sHLA-I-CD8 levels in the blood serum and EBC were discovered in patients with severe COPD.
The findings suggest a pathogenetic role of the investigated soluble molecules of the COPD development and allow considering the content of sCD8, sCD25, and sHLA-I-CD8 molecules as additional novel systemic and endobronchial markers of the progression of chronic inflammation of this disease.
American Psychological Association (APA)
Kubysheva, Nailya I.& Postnikova, Larisa& Soodaeva, Svetlana& Novikov, Viкtor& Eliseeva, Tatyana I.& Batyrshin, Ildar…[et al.]. 2017. Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152524
Modern Language Association (MLA)
Kubysheva, Nailya I.…[et al.]. Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152524
American Medical Association (AMA)
Kubysheva, Nailya I.& Postnikova, Larisa& Soodaeva, Svetlana& Novikov, Viкtor& Eliseeva, Tatyana I.& Batyrshin, Ildar…[et al.]. Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152524