MicroRNAs Involvement in Radioresistance of Head and Neck Cancer
Joint Authors
Slaby, Ondrej
Slampa, Pavel
Ahmad, Parwez
Sana, Jiri
Slavik, Marek
Smilek, Pavel
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer.
There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy.
Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis.
It has been found that regulation of these complex processes is often controlled by microRNAs.
MicroRNAs are short endogenous RNA molecules that posttranscriptionally modulate gene expression and their deregulated expression has been observed in many tumors including head and neck cancer.
Specific expression patterns of microRNAs have also been shown to predict prognosis and therapeutic response in head and neck cancer.
Therefore, microRNAs present promising biomarkers and therapeutic targets that might overcome resistance to radiation and improve prognosis of head and neck cancer patients.
In this review, we summarize the current knowledge of the functional role of microRNAs in radioresistance of cancer with special focus on head and neck cancer.
American Psychological Association (APA)
Ahmad, Parwez& Sana, Jiri& Slavik, Marek& Slampa, Pavel& Smilek, Pavel& Slaby, Ondrej. 2017. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152529
Modern Language Association (MLA)
Ahmad, Parwez…[et al.]. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152529
American Medical Association (AMA)
Ahmad, Parwez& Sana, Jiri& Slavik, Marek& Slampa, Pavel& Smilek, Pavel& Slaby, Ondrej. MicroRNAs Involvement in Radioresistance of Head and Neck Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152529