Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2PI3kAkteNOS Signalling Pathway
Joint Authors
Yao, Shun
Wu, Shaohong
Liu, Xing
Su, Chen
Hu, Da-Jun
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Studies show that aliskiren exerts favourable effects not only on endothelial progenitor cells (EPCs) but also on endothelial function.
However, the mechanism of the favourable effect of aliskiren on EPCs from patients with hypertension is unclear and remains to be further studied.
Methods.
The object of this study was to investigate and assess the in vitro function of EPCs pretreated with aliskiren.
After treated with aliskiren, the human EPCs were transplanted into a nude mouse model of carotid artery injury, and the in vivo reendothelialization of injured artery was estimated by staining denuded areas with Evans blue dye via tail vein injection.
Results.
We found that aliskiren increased the in vitro migration, proliferation, and adhesion of EPCs from patients with hypertension in a dose-dependent manner and improved the reendothelialization capability of these EPCs.
Furthermore, aliskiren increased the phosphorylation of Tie2, Akt, and eNOS.
After the blockade of the Tie2 signalling pathway, the favourable effects of aliskiren on the in vitro function and in vivo reendothelialization capability of EPCs were suppressed.
Conclusions.
This study demonstrates that aliskiren can improve the in vitro function and in vivo reendothelialization capability of EPCs from patients with hypertension via the activation of the Tie2/PI3k/Akt/eNOS signalling pathway.
These findings further indicate that aliskiren is an effective pharmacological treatment for cell-based repair in hypertension-related vascular injury.
American Psychological Association (APA)
Yao, Shun& Su, Chen& Wu, Shaohong& Hu, Da-Jun& Liu, Xing. 2020. Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2PI3kAkteNOS Signalling Pathway. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1152531
Modern Language Association (MLA)
Yao, Shun…[et al.]. Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2PI3kAkteNOS Signalling Pathway. Cardiology Research and Practice No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1152531
American Medical Association (AMA)
Yao, Shun& Su, Chen& Wu, Shaohong& Hu, Da-Jun& Liu, Xing. Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2PI3kAkteNOS Signalling Pathway. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1152531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152531