Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients
Joint Authors
Yang, Haotian
Ren, Zhongyuan
Zhang, Jun
Zhu, Mengyun
Zhao, Dongdong
Li, Shuang
Zheng, Yixing
Meng, Weilun
Zhang, Jingying
Xu, Yawei
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Catheter ablation combined with left atrial appendage closure (LAAC) was reported as a feasible strategy for atrial fibrillation (AF) patients with high risk of stroke or contraindications of oral anticoagulants.
We aimed to observe the short-term safety and efficacy of combining cryoballoon ablation (CBA) with LAAC in paroxysmal (PAF) patients.
Method and Results.
From Jan 2016 to Dec 2017, 304 patients diagnosed with nonvalvular, drug-refractory PAF were included, who underwent either CBA alone (n = 262) or combined procedure (n = 42).
Instant pulmonary vein isolation (PVI) with CBA was achieved in all patients, while successful LAAC achieved in 41 (97.6%) of combined procedure patients.
1-year freedom of AF rate was lower in combined procedure group (84.7% vs 70.7%, p=0.04), with unadjusted hazard ratio (HR = 1.97) and 95% confidence interval (CI) 1.03–3.77.
However, the multivariate COX model revealed left atrial diameter (p=0.002, HR = 1.10, and 95% CI 1.04, 1.17), rather than procedure type (p=0.51, HR = 1.34, and 95% CI 0.57, 3.17), was the predictor for freedom of AF.
Only 2 patients in the CBA group had stroke, contributing to the nonsignificant higher stroke incidence (p=1.00).
Transoesophageal echochardiography (TEE) achieved in 35 patients (83.3%) showed complete occlusion with no obvious residual flow (>3 mm), Device-related thrombosis, or pericardial perfusion.
All-cause mortality, rehospitalization, and complication rates were similar.
Conclusion.
Combining CBA with LAAC in a single procedure is a feasible strategy for PAF patients, with comparable short-term safety and efficacy to CBA alone.
American Psychological Association (APA)
Ren, Zhongyuan& Zhang, Jun& Zhu, Mengyun& Zhao, Dongdong& Li, Shuang& Yang, Haotian…[et al.]. 2020. Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152533
Modern Language Association (MLA)
Ren, Zhongyuan…[et al.]. Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients. Cardiology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1152533
American Medical Association (AMA)
Ren, Zhongyuan& Zhang, Jun& Zhu, Mengyun& Zhao, Dongdong& Li, Shuang& Yang, Haotian…[et al.]. Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1152533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152533