Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice
Joint Authors
Berr, Stuart S.
Tian, Yikui
Yang, Zequan
French, Brent A.
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
We hypothesized that daily administration of a potent antioxidant (α-lipoic acid: ALA) would protect the heart against both acute myocardial infarction (AMI) and left ventricular remodeling (LVR) post-AMI.
Methods and Results.
Two separate studies were conducted.
In the AMI study, C57Bl/6 mice were fed ALA daily for 7 d prior to a 45-minute occlusion of the left coronary artery (LCA).
Mean infarct size in control mice (fed water) was 60 ± 2%.
Mean infarct size in ALA-treated mice was 42 ± 3% in the 15 mg/kg·d group and 39 ± 3% in the 75 mg/kg·d group (both P<0.05 vs.
control).
In the LVR study, AMI increased LV end-systolic volume (LVESV) and reduced LV ejection fraction (LVEF) to a similar extent in both groups when assessed by cardiac MRI 1 day after a 2-hour LCA occlusion.
Treatment with ALA (75 mg/kg·d) or H2O was initiated 1 day post-AMI and continued until study’s end.
Both LVESV and LVEF in ALA-treated mice were significantly improved over control when assessed 28 or 56 days post-AMI.
Furthermore, the survival rate in ALA-treated mice was 63% better than in control mice by 56 days post-AMI.
Conclusions.
Daily oral ingestion of ALA not only protects mice against AMI but also attenuates LVR and preserves contractile function in the months that follow.
American Psychological Association (APA)
Yang, Zequan& Tian, Yikui& Berr, Stuart S.& French, Brent A.. 2020. Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152542
Modern Language Association (MLA)
Yang, Zequan…[et al.]. Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice. Cardiology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1152542
American Medical Association (AMA)
Yang, Zequan& Tian, Yikui& Berr, Stuart S.& French, Brent A.. Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152542