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Vitamin D (1,25-(OH)2D3) Improves Endothelial Progenitor Cells Function via Enhanced NO Secretion in Systemic Lupus Erythematosus
Joint Authors
Li, Jianbo
Liu, Lixiang
Huang, Zhenhua
Huang, Shufen
Feng, Shaozhen
Huang, Naya
Ai, Zhen
Long, Weiqing
Jiang, Lanping
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It has been proven that vitamin D was decreased and function of circulating endothelial progenitor cells (EPCs) was injured in systemic lupus erythematosus (SLE) patients.
However, the effect of vitamin D on the function of EPCs in vitro and its mechanism need further study.
Therefore, we investigated whether vitamin D improved the function of EPCs in vitro.
The peripheral blood mononuclear cells of the participants were isolated from SLE patients and control subjects and cultured to EPCs.
After the EPCs were treated with vitamin D (1,25-(OH)2D3), we evaluated the number, migratory and proliferative activities, and nitric oxide (NO) production of EPCs in vitro and detected vascular endothelial function by flow-mediated dilatation (FMD).
We found that vitamin D in a dose-dependent manner improved number and migratory and proliferative activities of EPCs from SLE patients.
Additionally, vitamin D upregulated NO production from EPCs in vitro.
A significant correlation between the FMD and plasma NO level was found.
There was also a correlation between number, migration, and proliferation of EPCs and NO production.
Thus, the present findings indicated that vitamin D improved the function of EPCs from SLE patients via NO secretion.
American Psychological Association (APA)
Huang, Zhenhua& Liu, Lixiang& Huang, Shufen& Li, Jianbo& Feng, Shaozhen& Huang, Naya…[et al.]. 2020. Vitamin D (1,25-(OH)2D3) Improves Endothelial Progenitor Cells Function via Enhanced NO Secretion in Systemic Lupus Erythematosus. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152549
Modern Language Association (MLA)
Huang, Zhenhua…[et al.]. Vitamin D (1,25-(OH)2D3) Improves Endothelial Progenitor Cells Function via Enhanced NO Secretion in Systemic Lupus Erythematosus. Cardiology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1152549
American Medical Association (AMA)
Huang, Zhenhua& Liu, Lixiang& Huang, Shufen& Li, Jianbo& Feng, Shaozhen& Huang, Naya…[et al.]. Vitamin D (1,25-(OH)2D3) Improves Endothelial Progenitor Cells Function via Enhanced NO Secretion in Systemic Lupus Erythematosus. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152549