A Panel of CA19-9, Ca125, and Ca15-3 as the Enhanced Test for the Differential Diagnosis of the Pancreatic Lesion
Joint Authors
Hogendorf, P.
Skulimowski, Aleksander
Durczyński, Adam
Kumor, Anna
Poznańska, Grażyna
Oleśna, Aleksandra
Rut, Joanna
Strzelczyk, J. M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma.
Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases.
The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca15-3, and CEA, when combined, can potentially yield an accurate test predicting pancreatic lesion etiology.
Methods.
We retrospectively analyzed data of 326 patients who underwent a diagnostic process due to pancreatic lesions of unknown etiology.
Results.
We found statistically significant differences in mean levels of all biomarkers.
In logistic regression model, we applied levels CA19-9, Ca125, and Ca15-3 as variables.
Two validation methods were used, namely, random data split into training and validation groups and bootstrapping.
Afterward, we built ROC curve using the model that we had created, reaching AUC = 0,801.
With an optimal cut-off point, it achieved specificity of 81,2% and sensitivity of 63,10%.
Our proposed model has superior diagnostic accuracy to both CA19-9 (p = 0,0194) and CA125 (p = 0,0026).
Conclusion.
We propose a test that is superior to CA19-9 in a differential diagnosis of pancreatic lesion etiology.
Although our test fails to reach exceptionally high accuracy, its feasibility and cost-effectiveness make it clinically useful.
American Psychological Association (APA)
Hogendorf, P.& Skulimowski, Aleksander& Durczyński, Adam& Kumor, Anna& Poznańska, Grażyna& Oleśna, Aleksandra…[et al.]. 2017. A Panel of CA19-9, Ca125, and Ca15-3 as the Enhanced Test for the Differential Diagnosis of the Pancreatic Lesion. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152561
Modern Language Association (MLA)
Hogendorf, P.…[et al.]. A Panel of CA19-9, Ca125, and Ca15-3 as the Enhanced Test for the Differential Diagnosis of the Pancreatic Lesion. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152561
American Medical Association (AMA)
Hogendorf, P.& Skulimowski, Aleksander& Durczyński, Adam& Kumor, Anna& Poznańska, Grażyna& Oleśna, Aleksandra…[et al.]. A Panel of CA19-9, Ca125, and Ca15-3 as the Enhanced Test for the Differential Diagnosis of the Pancreatic Lesion. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152561