The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis
Joint Authors
Song, Yong-xi
Gao, Peng
Wang, Zhen-ning
Ma, Bin
Zhang, Cong
Liu, Hongpeng
Xu, Yingying
Yu, Dehao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The potential impact that the intratumoral expression level of dihydropyrimidine dehydrogenase (DPD) has on chemotherapy sensitivity and long-term survival for gastric cancer (GC) patients remains controversial; therefore, this study seeks to clarify this issue.
Our meta-analysis was performed using Review Manager (RevMan) 5.3 software.
In vitro drug sensitivity tests, correlation coefficients between sensitivity to 5-fluorouracil (5-FU), and expression levels of intratumoral DPD were used as effective indexes to analyse.
Overall survival (OS) and progression-free survival (PFS) were used as endpoints for patient outcome, and hazard ratios (HRs) and 95% confidence intervals (CIs) were noted as measures of effect.
There were 15 eligible studies including 1805 patients for the final analysis.
The analysis revealed a statistically significant difference between the expression level of intratumoral DPD activity, DPD mRNA levels, and sensitivity to 5-FU in GC patients, with high expression levels of intratumoral DPD resulting in low sensitivity to 5-FU.
However, no matter what therapeutic regimens were used, there was no significant difference for patient outcomes between high and low DPD expression groups, either in OS or in PFS.
In conclusion, high levels of intratumoral DPD expression have a negative impact on sensitivity to 5-FU in GC patients, but no prognostic value for long-term survival was uncovered.
American Psychological Association (APA)
Zhang, Cong& Liu, Hongpeng& Ma, Bin& Song, Yong-xi& Gao, Peng& Xu, Yingying…[et al.]. 2017. The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152585
Modern Language Association (MLA)
Zhang, Cong…[et al.]. The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152585
American Medical Association (AMA)
Zhang, Cong& Liu, Hongpeng& Ma, Bin& Song, Yong-xi& Gao, Peng& Xu, Yingying…[et al.]. The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152585