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High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography
Joint Authors
Hoffmann, Ursula
Schoenberg, Stefan O.
Akin, Ibrahim
Henzler, Thomas
Behnes, Michael
Natale, Michele
Rusnak, Jonas
Reckord, Nadine
Hoffmann, Julia
Weidner, Kathrin
Lang, Siegfried
Mukherji, Agnibh
Kruska, Mathieu
Borggrefe, Martin
Bertsch, Thomas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) and the morphology of coronary artery plaques detected by coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease (CAD).
Methods.
Patients undergoing CCTA were prospectively enrolled.
CCTA was indicated by a low to intermediate pretest probability for CAD during routine clinical care.
Within 24 hours of CCTA examination, peripheral blood samples were taken to measure hsTnI, hsTnT, and N-terminal probrain natriuretic peptide (NT-proBNP).
Results.
A total of 99 patients were enrolled with 43% without CAD, 9% with noncalcified plaques, 28% with calcified plaques, and 19% with mixed type plaque lesions.
Both hsTnI and hsTnT levels were able to discriminate significantly between the groups, especially in the presence of mixed coronary plaques (AUC range: 0.741–0.752; p=0.0001).
In multivariate logistic regression models, hsTnT, but not hsTnI, was still significantly associated with mixed coronary plaque morphology (odds ratio = 8.968; 95% CI 1.999–40.241; p=0.004).
Conclusions.
Both hsTnI and hsTnT are able to discriminate between different coronary artery plaques morphologies, whereas hsTnT was significantly associated with mixed coronary plaques in patients with suspected CAD.
This trial is registered with NCT03074253.
American Psychological Association (APA)
Rusnak, Jonas& Behnes, Michael& Reckord, Nadine& Hoffmann, Ursula& Natale, Michele& Hoffmann, Julia…[et al.]. 2017. High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152604
Modern Language Association (MLA)
Rusnak, Jonas…[et al.]. High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152604
American Medical Association (AMA)
Rusnak, Jonas& Behnes, Michael& Reckord, Nadine& Hoffmann, Ursula& Natale, Michele& Hoffmann, Julia…[et al.]. High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152604