New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease
Joint Authors
Drożdż, Dorota
Zwolinska, Danuta
Bargenda-Lange, Agnieszka
Musiał, Kinga
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction and Aims.
Monocyte chemoattractant protein- (MCP-) 1, macrophage colony-stimulating factor (MCSF), and neopterin are connected with monocyte migration and transition into macrophages, leading to fibrosis and tubular damage in the course of CKD.
The aim of the study was to analyze the applicability of urinary fractional excretion (FE) of MCP1, MCSF, and neopterin, as markers of inflammation and tubular damage, in children with CKD.
Methods.
The study group consisted of 61 children with CKD stages 1–5 and 23 age-matched controls.
The serum and urine concentrations of MCP1, MCSF, and neopterin were assessed by ELISA and then the fractional excretion (FE) was calculated.
Results.
FE MCSF and neopterin values exceeded 1% already in controls.
FE MCSF rose significantly since CKD stages 1-2, FE neopterin since CKD stages 3–5.
FE MCP1 was below 1% in healthy controls and in CKD stages 1-2, then increased significantly in CKD stages 3–5.
Conclusions.
The FE MCP-1 values show that inflammation precedes the tubular dysfunction.
FE MCSF and FE neopterin may be considered new markers of the renal parenchyma progressive damage.
Fractional excretion may become a useful tool in the assessment of inflammation and tubular damage in children with CKD.
American Psychological Association (APA)
Musiał, Kinga& Bargenda-Lange, Agnieszka& Drożdż, Dorota& Zwolinska, Danuta. 2017. New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152606
Modern Language Association (MLA)
Musiał, Kinga…[et al.]. New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152606
American Medical Association (AMA)
Musiał, Kinga& Bargenda-Lange, Agnieszka& Drożdż, Dorota& Zwolinska, Danuta. New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152606