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The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population
Joint Authors
Xu, Shun
Liang, Li-li
Liu, Xin-guang
Xiong, Xing-dong
Cheng, Jie
Chen, Can
Cai, Meng-yun
Cen, Jin-ming
Yang, Xi-li
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
CXCL16 has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI).
Nonetheless, the role of the CXCL16 polymorphisms on MI pathogenesis is far to be elucidated.
We herein genotyped four tagSNPs in CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on individual susceptibility to MI.
Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1.03–1.66, and P=0.029) and CC genotype (OR = 1.84, 95% CI = 1.11–3.06, and P=0.018) of rs1050998 were associated with increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60–0.98, and P=0.036) of rs8123 exhibited decreased MI risk, while the other two tagSNPs had no significant effect.
Consistently, the haplotype rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02–1.96, and P=0.037).
Further stratified analysis unveiled a more apparent association with MI risk among younger subjects (≤60 years old).
Taken together, our results provided the first evidence that CXCL16 polymorphisms significantly impacted MI risk in Chinese subjects.
American Psychological Association (APA)
Xu, Shun& Cheng, Jie& Cai, Meng-yun& Liang, Li-li& Cen, Jin-ming& Yang, Xi-li…[et al.]. 2017. The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152609
Modern Language Association (MLA)
Xu, Shun…[et al.]. The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152609
American Medical Association (AMA)
Xu, Shun& Cheng, Jie& Cai, Meng-yun& Liang, Li-li& Cen, Jin-ming& Yang, Xi-li…[et al.]. The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152609