Measurement of Serum Klotho in Systemic Sclerosis
Joint Authors
Sarzi-Puttini, Piercarlo
Atzeni, Fabiola
Salaffi, Fausto
Talotta, Rossella
Bongiovanni, Sara
Letizia, Teresa
Rigamonti, Federica
Ditto, Maria Chiara
Batticciotto, Alberto
Gerardi, Maria Chiara
Antivalle, Marco
Vago, Tarcisio
Benucci, Maurizio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement.
Methods.
Blood samples obtained from both patients and controls were collected and analysed by an ELISA test for the determination of human soluble klotho.
Scleroderma patients were evaluated for disease activity through clinical, laboratory, and instrumental assessment.
Results.
Our cohort consisted of 81 SSc patients (74 females, mean age 63.9 ± 13.1 years) and 136 healthy controls (78 females, mean age 50.5 ± 10.7 years).
When matched for age, serum klotho concentration significantly differed between controls and patients (p<0.001).
However, in SSc patients, we did not find any significant association between serum klotho and clinical, laboratory, and instrumental findings.
Lower serum levels of klotho were detected in 4 patients who were anticitrullinated peptide antibody (ACPA) positive (p=0.005).
Conclusions.
Our data show a lower concentration of klotho in the serum of SSc patients compared to that of healthy controls, without any significant association with clinical manifestations and laboratory and instrumental findings.
The association between serum klotho and ACPA positivity requires further investigation.
American Psychological Association (APA)
Talotta, Rossella& Bongiovanni, Sara& Letizia, Teresa& Rigamonti, Federica& Ditto, Maria Chiara& Atzeni, Fabiola…[et al.]. 2017. Measurement of Serum Klotho in Systemic Sclerosis. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152613
Modern Language Association (MLA)
Talotta, Rossella…[et al.]. Measurement of Serum Klotho in Systemic Sclerosis. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152613
American Medical Association (AMA)
Talotta, Rossella& Bongiovanni, Sara& Letizia, Teresa& Rigamonti, Federica& Ditto, Maria Chiara& Atzeni, Fabiola…[et al.]. Measurement of Serum Klotho in Systemic Sclerosis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152613