MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study
Joint Authors
Gnetti, Letizia
Ampollini, Luca
Percesepe, Antonio
Alinovi, Rossella
Carbognani, Paolo
Mutti, Antonio
Rusca, Michele
Mozzoni, Paola
Corradi, Massimo
Goldoni, Matteo
Tiseo, Marcello
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying the disease development and progression.
Aims.
To identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients.
Methods.
miRNA-16, miRNA-17, miRNA-126, and miRNA-486 were quantified in plasma and formalin-fixed paraffin-embedded samples to evaluate their diagnostic and prognostic roles compared to patients with other noncancerous pulmonary diseases (controls).
Results.
The expression of all the miRNAs was significantly lower in patients with MPM and ASB than that in controls.
miRNA-16, miRNA-17, and miRNA-486 in plasma and tissue of MPM patients were significantly correlated.
Furthermore, the expression of miRNA-16 in plasma and tissue, and miRNA-486 only in tissue, was positively related with cumulative survival in MPM patients.
Conclusions.
All the miRNA levels were decreased in patients with MPM or ASB, supporting the role of circulating miRNAs as a potential tool for diseases associated with exposure to asbestos fibers.
miRNA-16 was directly related to MPM patient prognosis, suggesting its possible use as a prognostic marker in MPM patients.
American Psychological Association (APA)
Mozzoni, Paola& Ampollini, Luca& Goldoni, Matteo& Alinovi, Rossella& Tiseo, Marcello& Gnetti, Letizia…[et al.]. 2017. MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152621
Modern Language Association (MLA)
Mozzoni, Paola…[et al.]. MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152621
American Medical Association (AMA)
Mozzoni, Paola& Ampollini, Luca& Goldoni, Matteo& Alinovi, Rossella& Tiseo, Marcello& Gnetti, Letizia…[et al.]. MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152621