Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis
Joint Authors
Martins-Filho, Olindo Assis
Dusse, Luci Maria SantAna
Rios, Danyelle Romana Alves
Pinheiro, Melina Barros
de Oliveira Junior, Wander Valadares
Carvalho, Andréa Teixeira
Braga Gomes, Karina
Simões e Silva, Ana Cristina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hemodialysis is a modality of blood filtration in which accumulated toxins and water are removed from the body.
This treatment is indicated for patients at the end stage of renal disease.
Vascular access complications are responsible for 20–25% of all hospitalizations in dialyzed patients.
The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible, which is vital for the patient.
The aim of this study was to investigate inflammatory profile in patients undergoing hemodialysis as well as the association between these alterations and vascular access thrombosis.
A total of 195 patients undergoing hemodialysis have been evaluated; of which, 149 patients had not experienced vascular access thrombosis (group I) and 46 patients had previously presented this complication (group II).
Plasma levels of cytokines including interleukin (IL-) 2, IL-4, IL-5, IL-10, TNF-α, and IFN-γ were measured by cytometric bead array.
Our results showed that patients with previous thrombotic events (group II) had higher levels of the IL-2, IL-4, IL-5, and IFN-γ when compared to those in group I.
Furthermore, a different cytokine signature was detected in dialyzed patients according to previous occurrences or not of thrombotic events, suggesting that elevated levels of T-helper 1 and T-helper 2 cytokines might, at least in part, contribute to this complication.
American Psychological Association (APA)
Rios, Danyelle Romana Alves& Pinheiro, Melina Barros& de Oliveira Junior, Wander Valadares& Braga Gomes, Karina& Carvalho, Andréa Teixeira& Martins-Filho, Olindo Assis…[et al.]. 2017. Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152630
Modern Language Association (MLA)
Rios, Danyelle Romana Alves…[et al.]. Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152630
American Medical Association (AMA)
Rios, Danyelle Romana Alves& Pinheiro, Melina Barros& de Oliveira Junior, Wander Valadares& Braga Gomes, Karina& Carvalho, Andréa Teixeira& Martins-Filho, Olindo Assis…[et al.]. Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152630