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Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging
Author
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study explored the clinical value of plasma microRNA-21 as a novel biomarker for early prediction of stable and unstable angina patients and its relationship with aging.
A total of 255 participants, 123 patients with chronic stable angina, 82 patients with unstable angina, and 50 healthy subjects, were included in our study.
Stable coronary and unstable coronary patients were confirmed following AHA/ACC clinical protocols.
Total RNA was extracted from plasma by using miRNA-based TRIzol reagent.
Plasma miR-21 expression levels were determined by real-time polymerase chain reaction.
To evaluate the diagnosis accuracy, the receiver operating characteristic (ROC) curves were used.
Plasma microRNA-21 concentration levels were significantly elevated in stable and unstable angina patients as compared with control subjects P<0.001.
The area under the ROC curves of circulating microRNA-21 was accurately distinguished in stable angina patients (AUC 0.921) and unstable angina patients (AUC 0.944) from healthy subjects.
MicroRNA-21 expression gradually elevated with increasing aging in all the populations.
Moreover, the current study also demonstrated that the expression of plasma miR-21 levels was significantly associated with different age groups within healthy subjects and stable and unstable angina patients P<0.001.
This research finding suggested that plasma microRNA-21 may be considered as a suitable new biomarker for early detection of stable and unstable angina patients, and it has a strong correlation with aging.
American Psychological Association (APA)
Sayed, Ali Sheikh Md. 2020. Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152632
Modern Language Association (MLA)
Sayed, Ali Sheikh Md. Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging. Cardiology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1152632
American Medical Association (AMA)
Sayed, Ali Sheikh Md. Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152632