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Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia
Joint Authors
Pulkki, Kari
Korpelainen, Sini
Intke, Carina
Hämäläinen, Sari
Jantunen, Esa
Juutilainen, Auni
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Elevated levels of a cell surface glycoprotein, soluble cluster of differentiation 14 (sCD14), have been observed in patients with sepsis.
Only scarce data are available on sCD14 in hematological patients with chemotherapy-induced febrile neutropenia.
The study aim was to investigate sCD14 as an early biomarker in febrile neutropenia after intensive chemotherapy to detect a rapidly deteriorating clinical course early enough to avoid serious infectious complications.
Patients and Methods.
This prospective study included 87 adult hematological patients at the start of febrile neutropenia after intensive chemotherapy for acute myeloid leukemia or after autologous stem cell transplantation.
The study endpoints were septic shock, severe sepsis, and positive blood culture findings.
sCD14 was analyzed from day 0 to day 2, and its prognostic capacity was compared to that of C-reactive protein and procalcitonin.
Results.
Plasma level of sCD14 predicted the development of septic shock on day 1 (p=0.001) and day 2 but not the development of severe sepsis or blood culture positivity in hematological patients with chemotherapy-induced febrile neutropenia.
Conclusions.
Soluble CD14 did not predict an overall complicated course at the early stages of febrile neutropenia.
However, it was helpful in predicting the progression of the clinical course of neutropenic fever to septic shock.
American Psychological Association (APA)
Korpelainen, Sini& Intke, Carina& Hämäläinen, Sari& Jantunen, Esa& Juutilainen, Auni& Pulkki, Kari. 2017. Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152645
Modern Language Association (MLA)
Korpelainen, Sini…[et al.]. Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152645
American Medical Association (AMA)
Korpelainen, Sini& Intke, Carina& Hämäläinen, Sari& Jantunen, Esa& Juutilainen, Auni& Pulkki, Kari. Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152645