Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation
Joint Authors
Krisai, Philipp
Aeschbacher, Stefanie
Bossard, Matthias
Herber, Elena
Blum, Steffen
Meyre, Pascal
Burkard, Thilo
Kühne, Michael
Osswald, Stefan
Kaufmann, Beat A.
Conen, David
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The natural course of atrial fibrillation (AF) is not well defined.
We aimed to investigate the change in AF burden over time and its associated risk factors among AF patients.
Methods.
Fifty-four participants with recently documented paroxysmal or persistent AF were enrolled.
Main exclusion criteria were permanent AF or previous catheter ablation for AF.
AF burden was calculated as time in AF divided by total recording time using yearly continuous 7-day Holter-ECG recordings.
A relative change ≥10% or an absolute change >0.5% in AF burden between two yearly Holter-ECG recordings was considered significant.
Results.
Mean age was 67 years, 72% were men.
The proportion of patients with no recorded AF increased from 53.7% at baseline to 78.6% (p=0.1) after 4 years of follow-up.
In 7-day Holter-ECG recordings performed after baseline, 23.7% of participants had a decrease and 23.7% an increase in AF burden.
In separate mixed effect models, AF burden over time was associated with prior stroke (β 42.59, 95% CI (23.40; 61.77); p<0.0001), BNP (β 0.05, CI (0.02; 0.09); p=0.005) end-diastolic (β 0.49, CI (0.23; 0.74); p=0.0003) as well as end-systolic (β 0.25, CI (0.05; 0.46); p=0.02) left atrial volume, left atrial ejection fraction (β −0.43, CI (−0.76;−0.10); p=0.01), E-wave (β 36.67, CI (12.96; 60.38); p=0.003), and deceleration time (β −0.1, CI (−0.16; −0.05); p=0.002).
In a multivariable model, a history of prior stroke (β 29.87, CI (2.61; 57.13); p=0.03) and BNP levels (β 0.05, CI (0.01; 0.08); p=0.007) remained significantly associated with AF burden.
Conclusions.
Few patients with paroxysmal or persistent AF have AF episodes on yearly 7-day Holter-ECG recordings, and AF progression is rare.
AF burden was independently associated with a history of prior stroke and BNP levels.
American Psychological Association (APA)
Meyre, Pascal& Burkard, Thilo& Kühne, Michael& Osswald, Stefan& Kaufmann, Beat A.& Conen, David…[et al.]. 2020. Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152653
Modern Language Association (MLA)
Meyre, Pascal…[et al.]. Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation. Cardiology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1152653
American Medical Association (AMA)
Meyre, Pascal& Burkard, Thilo& Kühne, Michael& Osswald, Stefan& Kaufmann, Beat A.& Conen, David…[et al.]. Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152653