Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives
Joint Authors
Pradhan, Akshyaya
Bhandari, Monika
Sethi, Rishi
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Low-density lipoprotein lowering with statins has convincingly and consistently proven to reduce cardiovascular events in both primary and secondary prevention.
However, despite high-dose statin therapy, residual cardiovascular risk remains and many patients also do not tolerate statins.
Ezetimibe was initially projected as a frontline alternative to statin.
It is an intestinal cholesterol absorption inhibitor with modest LDL lowering effects.
But, major studies failed to demonstrate any beneficial effect of CV outcomes, and the drug was relegated to oblivion.
IMPROVE-IT, a contemporary, large, and well-designed trial, unequivocally demonstrated reduction in CV outcomes with ezetimibe when added to statin therapy.
The benefits are seen in both sexes, elderly, CKD, diabetes mellitus, and in patients with prior CABG.
It also reduces biomarkers and induces plaque regression like statins.
The drug has now established itself as an add-on therapy to statin when monotherapy fails to achieve LDL goals and when it is not tolerated.
The combination therapy has excellent safety and efficacy record.
It has now been endorsed by major guidelines too in management of dyslipidemia.
Yes, ezetimibe can indeed improve cardiovascular outcomes!
American Psychological Association (APA)
Pradhan, Akshyaya& Bhandari, Monika& Sethi, Rishi. 2020. Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152662
Modern Language Association (MLA)
Pradhan, Akshyaya…[et al.]. Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives. Cardiology Research and Practice No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1152662
American Medical Association (AMA)
Pradhan, Akshyaya& Bhandari, Monika& Sethi, Rishi. Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1152662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152662