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Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study
Joint Authors
Schempp, Christoph M.
Schwieger-Briel, Agnes
Kiritsi, Dimitra
Has, Cristina
Schumann, Hauke
Source
Dermatology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Skin fragility and recurrent wounds are hallmarks of hereditary epidermolysis bullosa (EB).
Treatment options to accelerate wound healing are urgently needed.
Oleogel-S10 contains a betulin-rich triterpene extract from birch bark.
In this study, we tested the wound healing properties of topical Oleogel-S10 in patients with dystrophic EB.
Methods.
We conducted an open, blindly evaluated, controlled, prospective phase II pilot trial in patients with dystrophic EB (EudraCT number 2010-019945-24).
Healing of wounds treated with and without topical Oleogel-S10 was compared.
Primary efficacy variable was faster reepithelialization as determined by 2 blinded experts.
The main secondary outcome variable of the study was percentage of wound epithelialization.
Results.
Twelve wound pairs of 10 patients with dystrophic EB were evaluated.
In 5 of 12 cases, both blinded reviewers considered epithelialization of the intervention wounds as superior.
In 3 cases, only one reviewer considered Oleogel-S10 as superior and the other one as equal to control.
Measurements of wound size showed a trend towards accelerated wound healing with the intervention but without reaching statistical significance.
Conclusion.
Our results indicate a potential for faster reepithelialization of wounds in patients with dystrophic EB when treated with Oleogel-S10 but larger studies are needed to confirm significance.
American Psychological Association (APA)
Schwieger-Briel, Agnes& Kiritsi, Dimitra& Schempp, Christoph M.& Has, Cristina& Schumann, Hauke. 2017. Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study. Dermatology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152676
Modern Language Association (MLA)
Schwieger-Briel, Agnes…[et al.]. Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study. Dermatology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152676
American Medical Association (AMA)
Schwieger-Briel, Agnes& Kiritsi, Dimitra& Schempp, Christoph M.& Has, Cristina& Schumann, Hauke. Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study. Dermatology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152676