A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression
Joint Authors
Sarris, J.
Murphy, Jenifer A.
Byrne, G. J.
Source
Depression Research and Treatment
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Major depression does not always remit.
Difficult-to-treat depression is thought to contribute to the large disease burden posed by depression.
Treatment-resistant depression (TRD) is the conventional term for nonresponse to treatment in individuals with major depression.
Indicators of the phenomenon are the poor response rates to antidepressants in clinical practice and the overestimation of the efficacy of antidepressants in medical scientific literature.
Current TRD staging models are based on anecdotal evidence without an empirical rationale to rank one treatment strategy above another.
Many factors have been associated with TRD such as inflammatory system activation, abnormal neural activity, neurotransmitter dysfunction, melancholic clinical features, bipolarity, and a higher traumatic load.
This narrative review provides an overview of this complex clinical problem and discusses the reconceptualization of depression using an illness staging model in line with other medical fields such as oncology.
American Psychological Association (APA)
Murphy, Jenifer A.& Sarris, J.& Byrne, G. J.. 2017. A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression. Depression Research and Treatment،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152698
Modern Language Association (MLA)
Murphy, Jenifer A.…[et al.]. A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression. Depression Research and Treatment No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152698
American Medical Association (AMA)
Murphy, Jenifer A.& Sarris, J.& Byrne, G. J.. A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression. Depression Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152698