Comparative Researches of Semen Arecae and Charred Semen Arecae on Gastrointestinal Motility, Motilin, Substance P, and CCK in Chronically Stressed Rats
Joint Authors
Wu, Chunjie
Peng, Wei
Zhang, Sanyin
Yang, Peng
Li, Xixiong
Wang, Xin
Song, Jiage
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To compare the effects of Semen Arecae (SA) and Charred Semen Arecae (CSA) on gastrointestinal motility, motilin, substance P (SP), and cholecystokinin (CCK) in chronically stressed rats.
Methods.
Rats were randomly divided into control group and stress group.
Rats in stress group were randomly exposed to a variety of unpredictable stimulations for 21 days.
Then, the rats were treated orally with distilled water, SA, CSA, and mosapride for 7 days.
Gastric residue rate and intestinal propulsion rate were evaluated.
Serum levels of motilin and SP were measured by enzyme-linked immunosorbent assay (ELISA).
CCK mRNA was quantified by using quantitative real-time PCR (qRT-PCR).
Results.
Both SA and CSA improved the intestinal propulsion and reduced the gastric residue in chronically stressed rats.
Furthermore, the serum levels of motilin and SP were significantly higher and the CCK mRNA expressions in intestine and hypothalamus were downregulated in SA and CSA groups.
Furthermore, it was found that CSA is more effective.
Conclusion.
Both SA and CSA enhanced gastrointestinal motility and increased serum levels of motilin and SP in chronically stressed rats via downregulating CCK mRNA expressions in intestine and hypothalamus.
Importantly, CSA possessed more effective promoting effects.
American Psychological Association (APA)
Zhang, Sanyin& Yang, Peng& Li, Xixiong& Wang, Xin& Song, Jiage& Peng, Wei…[et al.]. 2017. Comparative Researches of Semen Arecae and Charred Semen Arecae on Gastrointestinal Motility, Motilin, Substance P, and CCK in Chronically Stressed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152958
Modern Language Association (MLA)
Zhang, Sanyin…[et al.]. Comparative Researches of Semen Arecae and Charred Semen Arecae on Gastrointestinal Motility, Motilin, Substance P, and CCK in Chronically Stressed Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152958
American Medical Association (AMA)
Zhang, Sanyin& Yang, Peng& Li, Xixiong& Wang, Xin& Song, Jiage& Peng, Wei…[et al.]. Comparative Researches of Semen Arecae and Charred Semen Arecae on Gastrointestinal Motility, Motilin, Substance P, and CCK in Chronically Stressed Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152958