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Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats
Joint Authors
Xu, Haiyan
Wang, Xu
Liu, Mingming
He, Xueyuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study discussed the effect of Tangzhiqing granules on podocyte epithelial-mesenchymal transition in kidney of diabetic rats.
The diabetic rats were divided randomly into five groups: DM group treated with vehicle, Tangzhiqing granules low-dose treatment group, Tangzhiqing granules middle-dose treatment group, and Tangzhiqing granules high-dose treatment group.
Eight Wistar rats used as control group were given saline solution.
The intervention was all intragastric administration for 8 weeks.
At the end of the 8 weeks, biochemical parameters and kidney weight/body weight ratio were measured.
The kidney tissues were observed under light microscope and transmission electron microscopy.
To search for the underlying mechanism, we examined the epithelial-to-mesenchymal transition (EMT) related molecular markers and TGF-β/smad signaling pathway key proteins expression.
The results showed that Tangzhiqing granules relieved the structural damage and functional changes of diabetic kidneys.
Kidney podocyte EMT related molecular markers nephrin and CD2AP expression were increased, when desmin and α-SMA levels were decreased by Tangzhiqing granules in diabetic rats.
Further TGF-β/smad signaling pathway key proteins TGF-β1 and p-smad2/3 levels were decreased in diabetic rats after treatment with Tangzhiqing granules.
These findings suggest that Tangzhiqing granules may protect the podocytes of diabetic nephropathy rats via alleviating podocyte EMT and likely activating TGFβ/smad signaling pathway.
American Psychological Association (APA)
Xu, Haiyan& Wang, Xu& Liu, Mingming& He, Xueyuan. 2017. Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153005
Modern Language Association (MLA)
Xu, Haiyan…[et al.]. Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153005
American Medical Association (AMA)
Xu, Haiyan& Wang, Xu& Liu, Mingming& He, Xueyuan. Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153005