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Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats
Joint Authors
Lee, Ru-Ping
Wu, Wen-Tien
Yang, Wan-Ting
Ke, Chun-Yen
Tseng, Yi-Hsiung
Harn, Horng-Jyh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The main objective of wound treatments is to restore the functional skin properties and prevent infection.
Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies.
Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity.
In this study, AE and RE were applied in wound treatment to investigate their healing effects.
Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups.
The treatment and area measurement of wounds were applied daily for 21 days.
Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis.
Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P < 0.05).
Histological analysis showed that more inflammatory cell infiltration, collagen fibers, and myofibroblasts were observed in ARE treated group than those in NS group on days 3–5.
In ARE group, plasma IL-6 levels were elevated during days 3–5 (P > 0.05), and plasma TGF-β1 levels were significantly lower than those in the NS group on days 3-4 (P < 0.05).
In conclusion, ARE accelerates wound healing during inflammation and proliferation phases.
American Psychological Association (APA)
Yang, Wan-Ting& Ke, Chun-Yen& Wu, Wen-Tien& Harn, Horng-Jyh& Tseng, Yi-Hsiung& Lee, Ru-Ping. 2017. Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153028
Modern Language Association (MLA)
Yang, Wan-Ting…[et al.]. Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153028
American Medical Association (AMA)
Yang, Wan-Ting& Ke, Chun-Yen& Wu, Wen-Tien& Harn, Horng-Jyh& Tseng, Yi-Hsiung& Lee, Ru-Ping. Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153028