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Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa
Joint Authors
Merlugo, Liara
Santos, Marí C.
Sant’Anna, Liane S.
Moreira, Cleci M.
Mendez, Andreas S. L.
Limberger, Jéssica Tamara
Ehle, Catrine Santos
Fernandes, Maquelen Blanco
Paula, Fávero Reisdorfer
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Campomanesia xanthocarpa is known in Brazil as Guabiroba and is popularly used for various diseases, such as inflammatory, renal, and digestive diseases and dyslipidemia.
The aim of the study was to analyze the chemical composition and investigate the effects of aqueous extract of C.
xanthocarpa on the blood pressure of normotensive rats, analyzing the possible action mechanism using experimental and in silico procedures.
The extract was evaluated for total phenolic compounds and total flavonoid content.
The chemical components were determined by HPLC analyses.
Systolic and diastolic blood pressure and heart rate were measured with extract and drugs administration.
The leaves of C.
xanthocarpa presented the relevant content of phenolics and flavonoids, and we suggested the presence of chlorogenic acid, gallic acid, quercetin, and theobromine.
The acute administration of aqueous extract of C.
xanthocarpa has a dose-dependent hypotensive effect in normotensive rats, suggesting that the action mechanism may be mediated through the renin-angiotensin system by AT1 receptor blockade and sympathetic autonomic response.
Docking studies showed models that indicated an interaction between chlorogenic acid and quercetin with the AT1 receptor (AT1R) active site.
The findings of these docking studies suggest the potential of C.
xanthocarpa constituents for use as preventive agents for blood pressure.
American Psychological Association (APA)
Sant’Anna, Liane S.& Merlugo, Liara& Ehle, Catrine Santos& Limberger, Jéssica Tamara& Fernandes, Maquelen Blanco& Santos, Marí C.…[et al.]. 2017. Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153039
Modern Language Association (MLA)
Sant’Anna, Liane S.…[et al.]. Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153039
American Medical Association (AMA)
Sant’Anna, Liane S.& Merlugo, Liara& Ehle, Catrine Santos& Limberger, Jéssica Tamara& Fernandes, Maquelen Blanco& Santos, Marí C.…[et al.]. Chemical Composition and Hypotensive Effect of Campomanesia xanthocarpa. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153039