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Lectins, Interconnecting Proteins with BiotechnologicalPharmacological and Therapeutic Applications
Joint Authors
Barroso Coelho, Luana Cassandra Breitenbach
Lima, Vera Lúcia de Menezes
Silva, Priscila Marcelino dos Santos
Pontual, Emmanuel Viana
Correia, Maria Tereza dos Santos
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-07
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases.
These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer.
Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations.
Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds.
Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations.
Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems.
Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy.
Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.
American Psychological Association (APA)
Barroso Coelho, Luana Cassandra Breitenbach& Silva, Priscila Marcelino dos Santos& Lima, Vera Lúcia de Menezes& Pontual, Emmanuel Viana& Paiva, Patrícia Maria Guedes& Napoleão, Thiago Henrique…[et al.]. 2017. Lectins, Interconnecting Proteins with BiotechnologicalPharmacological and Therapeutic Applications. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1153043
Modern Language Association (MLA)
Barroso Coelho, Luana Cassandra Breitenbach…[et al.]. Lectins, Interconnecting Proteins with BiotechnologicalPharmacological and Therapeutic Applications. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-22.
https://search.emarefa.net/detail/BIM-1153043
American Medical Association (AMA)
Barroso Coelho, Luana Cassandra Breitenbach& Silva, Priscila Marcelino dos Santos& Lima, Vera Lúcia de Menezes& Pontual, Emmanuel Viana& Paiva, Patrícia Maria Guedes& Napoleão, Thiago Henrique…[et al.]. Lectins, Interconnecting Proteins with BiotechnologicalPharmacological and Therapeutic Applications. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1153043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153043