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Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
Joint Authors
Sakowicz, Agata
Lisowska, Michalina
Biesiada, Lidia
Gach, Agnieszka
Rybak-Krzyszkowska, Magda
Huras, Hubert
Sakowicz, Bartosz
Grzesiak, Mariusz
Pietrucha, Tadeusz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation.
The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia.
Methods.
Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies.
The distribution of genotypes for −1607 1G/2G MMP1, −735 C/T MMP2, −1306 C/T MMP2, −1171 5A/6A MMP3, and −1562C/T MMP9 polymorphisms was determined by RFLP-PCR.
Results.
The occurrence of 1G/1G MMP1 or 5A/5A MMP3 genotype in the mother or 1G/1G MMP1 or 5A/6A MMP3 genotype in the child is associated with preeclampsia development.
Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes by over 4.5 times.
No association between the carriage of studied MMP2 or MMP9 polymorphisms and the predisposition to preeclampsia was found.
Conclusion.
The maternal 1G/1G MMP1 and 5A/5A MMP3 and fetal 1G/1G MMP1 and 5A/6A MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.
American Psychological Association (APA)
Sakowicz, Agata& Lisowska, Michalina& Biesiada, Lidia& Rybak-Krzyszkowska, Magda& Gach, Agnieszka& Sakowicz, Bartosz…[et al.]. 2018. Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease Markers،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153068
Modern Language Association (MLA)
Sakowicz, Agata…[et al.]. Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease Markers No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1153068
American Medical Association (AMA)
Sakowicz, Agata& Lisowska, Michalina& Biesiada, Lidia& Rybak-Krzyszkowska, Magda& Gach, Agnieszka& Sakowicz, Bartosz…[et al.]. Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153068