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Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study
Joint Authors
Yeo, Min-kyung
Ham, Young Rok
Song, Chang Hun
Bae, Hong Jin
Jeong, Jin Young
Choi, Dae Eun
Na, Ki-Ryang
Lee, Kang Wook
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome.
No biomarker to predict the long-term prognosis of IMN is currently available.
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β superfamily and has been associated with chronic inflammatory disease.
It has the potential to be a useful prognostic marker in patients with renal diseases, such as diabetic nephropathy and IgA nephropathy.
This study examined whether GDF-15 is associated with the clinical parameters in IMN and showed that GDF-15 can predict IMN disease progression.
A total of 35 patients with biopsy-proven IMN, treated at Chungnam National University Hospital from January 2010 to December 2015, were included.
Patients younger than 18 years, those with secondary membranous nephropathy, and those lost to follow-up before 12 months were excluded.
Levels of GDF-15 at the time of biopsy were measured using enzyme-linked immunosorbent assays.
Disease progression was defined as a ≥30% decline in estimated glomerular filtration rate (eGFR) or the development of end-stage renal disease.
The mean follow-up was 44.1 months (range: 16–72 months).
Using receiver operating curve analysis, the best serum GDF-15 cut-off value for predicting disease progression was 2.15 ng/ml (sensitivity: 75.0%, specificity: 82.1%, p=0.007).
GDF-15 was significantly related to age and initial renal function.
In the Kaplan-Meier analysis, the risk of disease progression increased in patients with GDF-15 ≥ 2.15 ng/ml when compared with those with GDF-15 < 2.15 ng/ml (50.0% versus 9.7%) (p=0.012).
In the multivariate Cox regression analysis adjusted for potential confounders, only GDF-15 was significantly associated with disease progression in IMN (p=0.032).
In conclusion, the GDF-15 level at the time of diagnosis has a significant negative correlation with initial renal function and is associated with a poor prognosis in IMN.
Our results suggest that GDF-15 provides useful prognostic information in patients with IMN.
American Psychological Association (APA)
Ham, Young Rok& Song, Chang Hun& Bae, Hong Jin& Jeong, Jin Young& Yeo, Min-kyung& Choi, Dae Eun…[et al.]. 2018. Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153075
Modern Language Association (MLA)
Ham, Young Rok…[et al.]. Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153075
American Medical Association (AMA)
Ham, Young Rok& Song, Chang Hun& Bae, Hong Jin& Jeong, Jin Young& Yeo, Min-kyung& Choi, Dae Eun…[et al.]. Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153075