Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component
Joint Authors
Ieni, A.
Alberto Caruso, Rosario
Angelico, Giuseppe
Giuffrè, Giuseppe
Arena, Francesco
Barresi, Valeria
Tuccari, Giovanni
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
A cribriform architectural pattern has been reported in 9% of one unselected consecutively collected series of gastric carcinomas (GC) with unfavourable prognostic outcome.
Taking into consideration the biological relevance of the human epidermal growth factor receptor 2 (HER2) status, we have analyzed a cohort of GC with a cribriform component more than 40% (CGC) to evaluate the HER2 amplification rate as a potential target for therapy with trastuzumab.
Results.
HER2 overexpression was encountered in 21 of 100 (21%) GC; a progressive increase in HER2 amplification was appreciated moving from non-CGC (20.6%) towards CGC cases (21.6%), although this difference does not reach a statistical significance.
Nevertheless, either in univariate or in multivariate analyses, stage and HER2 status showed a significant p value (<0.001) in CGC patients.
Conclusions.
Our data confirmed a worse prognosis in all CGC patients with HER2 amplification, resulting in a shorter survival time.
We invite all pathologists in their daily practice to specify the occurrence of cribriform neoplastic component in GC, either in surgical or in bioptical samples, taking into practical assessment the high HER2 overexpression rate in order to correctly treat these patients with worse behavior.
American Psychological Association (APA)
Ieni, A.& Angelico, Giuseppe& Barresi, Valeria& Giuffrè, Giuseppe& Arena, Francesco& Alberto Caruso, Rosario…[et al.]. 2018. Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153083
Modern Language Association (MLA)
Ieni, A.…[et al.]. Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153083
American Medical Association (AMA)
Ieni, A.& Angelico, Giuseppe& Barresi, Valeria& Giuffrè, Giuseppe& Arena, Francesco& Alberto Caruso, Rosario…[et al.]. Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153083