Positive Correlation of Serum N-Acetyl-β-hexosaminidase with Markers of Atherosclerosis in Diabetes Type 2 Patients with Mild Symptoms of Depression and Anxiety
Joint Authors
Waszkiewicz, Napoleon
Chojnowska, Sylwia
Cabaj-Wiater, Iwona
Mikulska-Baran, Aleksandra
Zalewska-Szajda, Beata
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Analysis of the correlation between diabetes type 2 (DT2) and serum N-acetyl-β-hexosaminidase (HEX) activity with parameters of fat metabolism and symptoms of anxiety and depression.
Material and Method.
The study was performed using a random sample of 40 DT2 patients (22 women and 18 men) between the ages of 43 and 71 (median 59) and 40 control persons (28 women and 12 men) between the ages of 18 and 64 (median 46).
The activity of HEX was determined by a colorimetric method.
The activity of the serum exoglycosidase was expressed in pkat/mL.
Each participant underwent Hamilton tests, to evaluate level of anxiety and depression.
Additionally, the HEX activity and concentration of particular lipidograms were monitored using a blood sample from each participant.
Results.
In DT2 patients, a significant positive correlation was found between serum HEX activity and the concentration of serum cholesterol LDL fractions, triacylglycerols (TAG), and Castelligro atherogenic indexes.
A significantly increased level of anxiety and depression in comparison to the control group was found as well.
Conclusion.
Serum HEX activity in DT2 patients is a better marker of atherosclerosis than serum total cholesterol level in persons with mild symptoms of depression and anxiety.
In DT2 patients, a routine testing of anxiety and depression is recommended.
Early detection of these disorders creates the possibility for treatment, an improvement in a patient’s quality of life, and the overall longevity of DT2 patients.
American Psychological Association (APA)
Chojnowska, Sylwia& Cabaj-Wiater, Iwona& Mikulska-Baran, Aleksandra& Zalewska-Szajda, Beata& Waszkiewicz, Napoleon. 2018. Positive Correlation of Serum N-Acetyl-β-hexosaminidase with Markers of Atherosclerosis in Diabetes Type 2 Patients with Mild Symptoms of Depression and Anxiety. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153099
Modern Language Association (MLA)
Chojnowska, Sylwia…[et al.]. Positive Correlation of Serum N-Acetyl-β-hexosaminidase with Markers of Atherosclerosis in Diabetes Type 2 Patients with Mild Symptoms of Depression and Anxiety. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153099
American Medical Association (AMA)
Chojnowska, Sylwia& Cabaj-Wiater, Iwona& Mikulska-Baran, Aleksandra& Zalewska-Szajda, Beata& Waszkiewicz, Napoleon. Positive Correlation of Serum N-Acetyl-β-hexosaminidase with Markers of Atherosclerosis in Diabetes Type 2 Patients with Mild Symptoms of Depression and Anxiety. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153099