Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4NF-κB Pathway
Joint Authors
Zhan, Janis Ya-xian
Wang, Xiu-Fen
Li, Yu-Cui
Xu, Lie-Qiang
Yu, Xiu-Ting
Gui, Shu-Hua
Xie, Jian-hui
Su, Zu-Qing
Xie, You-Liang
Lai, Xiao-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Li-Fei-Xiao-Yan prescription (LFXY) has been clinically used in China to treat inflammatory and infectious diseases including inflammatory lung diseases.
The present study was aimed at evaluating the potential therapeutic effects and potential mechanisms of LFXY in a murine model of lipopolysaccharide- (LPS-) induced acute lung injury (ALI).
In this study, the mice were orally pretreated with LFXY or dexamethasone (positive drug) before the intratracheal instillation of LPS.
Our data indicated that pretreatment with LFXY enhanced the survival rate of ALI mice, reversed pulmonary edema and permeability, improved LPS-induced lung histopathology impairment, suppressed the excessive inflammatory responses via decreasing the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokine (MIP-2) and inhibiting inflammatory cells migration, and repressed oxidative stress through the inhibition of MPO and MDA contents and the upregulation of antioxidants (SOD and GSH) activities.
Mechanistically, treatment with LFXY significantly prevented LPS-induced TLR4 expression and NF-κB (p65) phosphorylation.
Overall, the present study suggests that LFXY protected mice from acute lung injury induced by LPS via inhibition of TLR4/NF-κB p65 activation and upregulation of antioxidative enzymes and it may be a potential preventive and therapeutic agent for ALI in the clinical setting.
American Psychological Association (APA)
Xu, Lie-Qiang& Yu, Xiu-Ting& Gui, Shu-Hua& Xie, Jian-hui& Wang, Xiu-Fen& Su, Zu-Qing…[et al.]. 2017. Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153109
Modern Language Association (MLA)
Xu, Lie-Qiang…[et al.]. Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1153109
American Medical Association (AMA)
Xu, Lie-Qiang& Yu, Xiu-Ting& Gui, Shu-Hua& Xie, Jian-hui& Wang, Xiu-Fen& Su, Zu-Qing…[et al.]. Protective Effects of Li-Fei-Xiao-Yan Prescription on Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Oxidative Stress and the TLR4NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1153109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153109