Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice
Joint Authors
Cuman, Roberto Kenji Nakamura
Silva, Expedito Leite
Silva-Comar, Francielli Maria de Souza
Silva-Filho, Saulo Euclides
Cardia, Gabriel Fernando Esteves
Uchida, Nancy Sayuri
Cremer, Edivaldo
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High doses of acetaminophen (APAP) lead to acute liver damage.
In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP.
The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral.
The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis.
The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro.
Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production.
The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment.
Citral inhibited neutrophil migration and exhibited antioxidant activity.
Our results suggest that citral protects the liver against liver toxicity induced by APAP.
American Psychological Association (APA)
Uchida, Nancy Sayuri& Silva-Filho, Saulo Euclides& Cardia, Gabriel Fernando Esteves& Cremer, Edivaldo& Silva-Comar, Francielli Maria de Souza& Silva, Expedito Leite…[et al.]. 2017. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153117
Modern Language Association (MLA)
Uchida, Nancy Sayuri…[et al.]. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153117
American Medical Association (AMA)
Uchida, Nancy Sayuri& Silva-Filho, Saulo Euclides& Cardia, Gabriel Fernando Esteves& Cremer, Edivaldo& Silva-Comar, Francielli Maria de Souza& Silva, Expedito Leite…[et al.]. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153117
